Pii: S0887-2333(98)00048-4
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چکیده
ÐThe ototoxic damage that drugs such as neomycin, kanamycin, colistin, cisplatin, transplatin and carboplatin cause on outer and inner hair cells in postnatal day 3 rat cochlear explants was investigated. Phalloidin± ̄uorescein conjugate-stained stereocilia bundles of sensory hair cells were quanti®ed by video image analysis as a measurement of ototoxic eect. The video image quanti®cation system established dose±response curves for ototoxic drugs (e.g. calculation of an IC50) and allowed comparisons between several ototoxins from the same family. This methodology provided the means to assess the ecacy of otoprotectant agents in preventing ototoxicity. Poly-l-aspartate (10ÿ5 M) and poly-l-glutamate (10ÿ5 M) protected auditory hair cells from neomycin (10ÿ3 M) toxicity while reduced glutathione (10ÿ3 M) provided protection against cisplatin (10ÿ4 M)-induced hair cell damage. # 1998 Published by Elsevier Science Ltd. All rights reserved
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تاریخ انتشار 1998